Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes sharma k, khosla p k, tiwari h k, sharma r k, bajaj j s – indian j ophthalmol

Juvenile diabetics have severe loss of beta cell function and require replacement therapy with insulin. Signs of type 1 diabetes in child Insulin antigenicity can produce anti-insulin antibodies resulting in allergic reactions and insulin resistance. Type 1 diabetes in babies The role of insulin-anti-insulin antibody complexes in the development and progress of chronic diabetic complications like microangiopathy is not very clear. Type 1 diabetes statistics In the present study, there was statistically a significant trend of higher insulin antibody binding levels in IDDM patients who developed retinopathy.


Juvenile onset diabetes Though there was a trend of higher insulin antibody in IDDM patients with retinopathy, there was no association between insulin antibody and HLA antigen which some authors have reported.

How to cite this article: Sharma K, Khosla P K, Tiwari H K, Sharma R K, Bajaj J S. Difference between type1 and type 2 diabetes symptoms Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes. Difference between type1 and type 2 diabetes Indian J Ophthalmol 1991;39:174-5

How to cite this URL: Sharma K, Khosla P K, Tiwari H K, Sharma R K, Bajaj J S. Type 1 diabetes autoimmune disease Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes. Type 1 diabetes ppt Indian J Ophthalmol [serial online] 1991 [cited 2017 Jan 31];39:174-5. Type 1 diabetes in toddlers Available from: http://www.ijo.in/text.asp?1991/39/4/174/24429

Juvenile diabetics have severe loss of beta cell function and require replacement therapy with insulin. Type 1 diabetes life expectancy 2015 Insulin antigenicity can produce anti-insulin antibodies resulting in allergic reactions [1] and insulin resistance [2] The role of insulin-anti-insulin antibody complexes in the development and progress of chronic diabetic complications like microangiopathy is not very clear. Cure type 1 diabetes naturally The present study investigates the relationship be­tween anti-insulin antibody and retinopathy in insulin dependent diabetes mellitus (IDDM).

Thirty five patients of IDDM were studied for the presence of diabetic retinopathy by fluorescein an­giography. Diabetes type 1 life expectancy They were divided into various groups depending on the severity of retinopathy [3]: Group I-no retinopathy (20 patients); Group II with retinopathy (15 patients) further subdivided into Ila – mild retinopathy (6 patients) and Ilb – severe retinopathy (proliferative and maculopathy, 9 patients).

Patients showing loss of beta cell function indicated by low serum C peptide immunoreactivity (RIA kit,Novo Research Institute, Denmark) and low serum immunoreactive insulin [4]; both baseline and after glucose load, were included in the study.

Serum insulin antibody: Fasting blood samples were analysed for insulin antibody by radioimmunoassay (RIA) [5]. Type 1 diabetes autoimmune Percentage of insulin binding was determined by a RIA procedure usin dextran coated charcoal method and titration with 125 insulin (monocomponent porcine insulin; Novo Research Institute, Im­munochemical Laboratory, Denmark). Juvenile diabetes mellitus Percentage of insulin antibody binding was estimated in undiluted serum and after dilutions i.e. How to reverse type 1 diabetes 1:10, 1:50 and 1:100.

Insulin antibody binding: The binding of 125 labelled pork insulin by the serum sample in IDDM (35 patients), were expressed as percent of labelled insulin bound [Figure – 1]. Type 1 diabetes symptoms in adults Sixty percent of patients with retinopathy and only 20% without retinopathy had moderate or high serum insulin binding levels. Type 1 diabetes insulin dependent This difference was statistically significant ( [Table – 1]. Type 1 diabetes symptoms adults P>0.05). Type 1 diabetes life expectancy Mean values of percentage of insulin an­tibody binding in retinopathy group was also higher than the no-retinopathy group [Table – 2], but this failed to reach statistical significance.

Some workers have suggested that immune com­plexes may play a role in the degenerative diseases of diabetes including microangiopathy [7]. Type 1 diabetes nhs The antigen antibody complexes in the plasma of diabetics are partially due to insulin and its antibodies [8]. Type 1 diabetes insulin resistance Cytotoxic immune complexes could be formed as a combination of high affinity insulin antibody with previously se-questered insulin in the vascular wall.

In the present study, there was statistically a sig­nificant trend of higher insulin antibody binding levels in IDDM patients who developed retinopathy [Table – 1]. Type 1 diabetes pregnancy symptoms Anderson [9] has also found that the frequency of high insulin antibody titre was significantly greater among diabetics with complications like retinopathy and insulin-antinsulin antibody complexes may be involved in aggravating the microvascular pathology. Difference between type1 and type 2 diabetes mellitus Other workers have failed to find such a relationship [10]

Evidence is slim but increasing to support that diabetic microangiopathy may be caused or ac­celerated by immune complexes. Type 1 diabetes complications timeline Atkins et al [11] have found strong correlation between the insulin antibody and islet cell antibody and presence of both increased the likelihood of autoimmune phenomenon.

HLA and insulin antibody: The susceptibility to retinopathy in IDDM has been correlated with par­ticular HLA antigens [12]. Type 1 diabetes insulin dosing The possibility that this could be mediated by production of insulin antibodies has been investigated. Type 1 diabetes symptoms child In our present study, though there was a trend of higher insulin antibody in IDDM patients with retinopathy, there was no association between insulin antibody and HLA antigen [Table – 3]. Type 1 diabetes prognosis Some workers [10] have found such an association with HLA 15 but others have failed to confirm it [13] In conclusion, the higher levels of anti-insulin antibody seen in patients of IDDM with retinopathy did not show any association with HLA. Gestational diabetes numbers chart It remains speculative whether raised levels of anti-insulin antibody have a role to play in either initiation or aggravation of retinopathy or alternatively they may simply be a reflection of non specific secondary tissue damage

Thirty five patients of insulin dependent diabetes mellitus (IDDM) were investigated for retinopathy by fluorescein angiography. Type 1 diabetes mellitus definition Serum levels of insulin an­tibody binding were correlated with the retinopathy. Type 1 diabetes mellitus symptoms Patients with retinopathy had a trend towards higher serum insulin antibody binding levels which was statistically significant. Definition of type 1 diabetes There was no association between HLA phenotypes and the insulin antibody levels.