Could a future cure for migraines come from a chance discovery in the past do i have a hormonal imbalance

The main purpose of this mRNA editing process is to remove extra regulatory information — essentially notes in the margins of a recipe — known as introns. These need to be separated from the protein-coding parts, which are called exons. But the mRNA editing process also makes it possible to create multiple products from the same recipe by modifications — for example, removing both exons and introns, like you would omit walnuts if you didn’t like nuts in your banana bread. This is called “alternative splicing,” and it’s one of the reasons why human DNA doesn’t require more genes than plants and animals that are usually thought of as “less complex.”

Amara and Rosenfeld had discovered one of the first examples of RNA splicing at work: CGRP and calcitonin were produced by the same gene, but very different due to mRNA editing.

Further research suggested that, as opposed to calcitonin, which is mainly produced in the thyroid, CGRP was mainly found in the brain, especially in a region called the hypothalamus.

Once they published their findings, other researchers in completely different fields took up the case. Neurologists Lars Edvinsson and Peter Goadsby, for example, initially found CGRP was elevated in the blood of patients experiencing migraines, showing a correlation between CGRP and the severe headaches. But the scientists still needed to show causation — thankfully, a group of selfless volunteers stepped up to the task and allowed themselves to be injected with potentially migraine-inducing hormones in the name of science. Sure enough, the volunteers who received CGRP experienced migraine-like symptoms, while those who received a placebo were unaffected.

Even though exactly how CGRP is connected to migraines is still unclear, evidence for its role has only strengthened over the last few decades. The current idea is that CGRP binds to specific receptors and sensitizes nerves in the head, face, and jaw known as the trigeminal nerves. This helps transmit pain signals, trigger inflammation, and increase blood flow. So scientists began to wonder how to use CGRP or its receptors to develop migraine medication, and pharmaceutical companies began investing in the search.

Initially, researchers looked for chemicals called small molecules, like those in many conventional drugs. While there were a few promising leads, they turned out to be toxic. An alternative strategy pursued antibodies, proteins that recognize and bind to specific sites on other molecules: They’re how your body recognizes molecules as foreign and targets them for destruction. Researchers hoped that they might be able to find an antibody that binds to CGRP receptors, effectively intercepting the migraine-inducing message.

Early attempts at using mouse antibodies in humans failed, because the antibodies themselves registered as foreign and the immune system destroyed them. To overcome this obstacle, scientists in the late 1990s engineered mice called “ XenoMice,” whose antibody genes had been replaced with human antibody genes, so that antibodies the mice made would be “humanized.” In the search for a migraine antibody treatment, researchers injected these mice with human CGRP receptors. The XenoMice then produced humanized antibodies, and scientists isolated the ones that bound to the CGRP receptor. One antibody that seemed promising was erenumab.

A benefit of antibodies is that they can be incredibly selective — other important and naturally occurring molecules have receptors very similar to CGRP’s, so any potential treatment would have to not block various other receptors. Additionally, antibodies are long-lasting; while injections may not be fun, they’d only have to be administered once a month.

Pharmacutical company Novartis (working with Amgen) recently conducted a 12-week, double-blind controlled Phase III trial of Erenumab. During the trial, patients receiving Erenumab (Aimovig™) had significantly fewer migraine days than patients receiving a placebo, and many patients saw improvement in their ability to function. But despite causing an average reduction in headaches, the “response rate” was fairly low; only 30 percent saw at least a 50 percent reduction in migraine days, meaning more than half of the patients receiving the drug saw no significant benefit compared to a placebo. In the patients where the treatment did work, however, it had a big effect; many saw vast symptom improvement. Novartis just announced the encouraging results, and the treatment is slated for FDA approval next month.

It’s unclear whether it will be as a first-line treatment, available to all migraine sufferers, or reserved for more difficult-to-treat cases. And it’s too early to know whether long-term use of Erenumab could have side-effects. This is particularly an issue because, as Erenumab is a preventative medicine, it would have to be taken regularly, long-term. The main concern is the risk of blood clotting events, such as ischemic strokes and heart attacks, because CGRP also plays a role in expanding blood vessels.

Finally, of course, is the question of cost. These drugs are likely to be much more expensive that currently-available treatments, especially until (and if) generic versions become available. However, in addition to Erenumab, which targets the CGRP receptor, there are several other mAbs in clinical trials that target CGRP itself, so competition could potentially bring this price tag down.