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Vanadyl Sulfate has partially restored insulin production, protected the size and content of pancreatic islets, maintained glucose tolerance regardless of insulin levels, maintained levels of glucose, lipids, creatinine and thyroid hormone, and corrected heart function and glycerol output from adipose tissue.

Research shows that the average person consumes 12 pounds of sugar a year. The re­sults of this sugar binge are: hy­perinsulinemia, hyperlipidemia, obesity, cardiovascular disease, diabetes, Syndrome X, A.G.E. products, cataracts, and various forms of neuropathy. These are the chronic diseases of our times. The frontline organ deal­ing with this glucose onslaught is the pancreas. The increasing levels of diabetes and dysglyce­mia problems are indicators that the pancreas is not up to dealing with this level of sweetness.

Gymnema sylvestre, a woody climber from the tropical forests of India, has been shown to have the potential to re­pair/revitalize/regenerate the pancreas. Tests in humans with both Type I and Type II diabetes Gym­nema were shown to be have good effect. Gymnema extract was able to contribute to the reduction of blood glucose, glycated hemoglobin, glycosylated plasma proteins, increased C-­peptide levels and conventional diabetic drug therapy. These effects are not noted with stan­dard conventional therapy. All patients developed secondary hypoglycemic symptoms and had to have their drug dosages reduced after several weeks.

When tested on healthy individu­als, Gymnema does not produce any acute reduction in fasting blood glucose levels. This re­search is starting to overturn the conventional concept that the pancreatic beta cell in juve­nile, maturity-onset, and ex­perimentally-induced diabetes is irreversible.

In Sanskrit, Gymnema was known as Meshashringl and in Hindu as Gurmar. Both names refer to its ability to destroy sugar. Gym­nema has the interesting prop­erty of being able to stop sweet taste. This property was investi­gated in the early 1900’s in a crude fraction known as ‘gymnemic acid’. This fraction not only stopped sweet taste but glycouria as well.

Vanadyl sulfate, a salt of the mineral vanadium (vanadium oxysulfate), has demonstrated insulin-like effects on glucose metabolism. Clinical trials have shown a significant de­crease in insulin requirements by patients with insulin-dependent diabetes mellitus after Vanadyl sulfate therapy and a significant decrease in cholesterol levels in both insulin-dependent and non-­insulin-dependent diabetics.

Vitamin B3, also called Niacin, Niocinamide, or Nicotinic Acid, is an essential nutrient required by all humans for the proper metabolism of carbohydrates, fats, and proteins, as well as for the production of hydrochloric acid for digestion. Vitamin B3 also sup­ports proper blood circulation, healthy skin, and aids in the functioning of the central nerv­ous system. Because of its role in supporting the higher func­tions of the brain and cognition, vitamin B3 may play an impor­tant role in the treatment of many cognitive disorders. Lastly, adequate levels of B3 are vital for the proper synthesis of insulin and the sex hormones, such as estrogen, testosterone, and progesterone.

Research in recent years has been published showing that chromium in its non-toxic, triva­lent state bound in an organic complex with nicotinic acid as Glucose Tolerance Factor (GTF) improves insulin function In vitro and in vivo. Most chromium used as a GTE supplement comes from Brewer’s yeast. Chromium in Brewer’s yeast is in the Polynicotinate form. Chro­mium Polynicotinate is up to 300% more bio-available than chromium picolinate.

Chromium doesn’t stimulate the increase of insulin, but rather acts in potentiating the action of the hormone. Human trials have shown that chromium works in the following ways: re­duces fasting glycemia, mean blood glucose, and glycated he­moglobin. It lowers cholesterol and triglycerides but less than the other indices.

One factor affecting chromium stores is the body is the amount of sugar that an individual con­sumes. Once chromium has acted as a cofactor in insulin re­sponse, it is excreted in the urine. With the high sugar diet of today, the turnover rate of chromium is quite high. In patients with the highest risk for developing frank diabetes, they need chromium the most. The highest tissue stores of chromium occur in newborns. As the result of diet and sugar stress, chromium is depleted from the body as we age. Studies have shown that diabetics have lower plasma chromium levels than non-diabetics.

Niacin-bound chromium is more bio-available than chromium picolinate. A recent animal study at the University of California found that Chromium Polynicoti­nate was absorbed and retained up to 311% better than chromium picolinate and 672% better than chromium chloride.