Toxic topic_ the use of antiemetic drugs to treat vomiting caused by acute gastroenteritis

[Show abstract] [Hide abstract] ABSTRACT: The aim of this study was to determine the effect of oral ondansetron in decreasing the vomiting due to acute gastroenteritis in children.

In a single center, randomized, double blind, controlled trial, the effect of oral ondansetron was compared with placebo on 176 patients between 1 and 10 years old with acute gastroenteritis. Best antiemetic for children 30 minutes after drug administration, oral rehydration therapy (ORT) was initiated.


Strong antiemetic Severity of vomiting was evaluated during emergency department (ED) stay and 48 hours follow up. Over the counter antiemetic uk Data were collected and analyzed by SPSS16.

Fifty two of children (58.5%) were males with the mean age of 3.12 (±2.30) years. Antiemetic drugs safe in pregnancy Ten patients in ondansetron and 14 in placebo group had persistent vomiting during ED stay. Antiemetic safe during pregnancy After analyzing, there was no significant relation between vomiting in 4 and 48 hours and need for intra venous fluid therapy between the two groups although ondansetron generally decreased ORT failure (P=0.03).

Although administrayion of oral ondansetron in gastroenteritis could decrease failure of ORT, it seems that further well-conducted clinical studies are needed to determine effects of oral ondansetron precisely.

[Show abstract] [Hide abstract] ABSTRACT: Vomiting as a consequence of gastroenteritis frequently occurs in children. Otc antiemetic uk It is still debatable whether vomiting should be treated with antiemetic drugs.

A randomized, double blind, placebo-controlled trial was performed in our emergency departments. Pregnancy safe antiemetics Children, aged 5 months to 8 years, were randomized to receive either ondansetron 0.2 mg/kg or placebo at 8h intervals. New antiemetic for chemotherapy The primary outcome measure was the frequency of emesis during an 8-h-period after enrollment.

A hundred and nine patients were enrolled; 54 received placebo and 55 received ondansetron. Meclizine hcl 25 mg antiemetic As compared with the children who received placebo, children who received ondansetron were less likely to vomit both during the first 8-h follow-up in the emergency department [relative risk (RR): 0.33, 95% CI: 0.19-0.56, NNT: 2, 95% CI: 1.6-3.5], and during the next 24-h follow-up (RR: 0.15, 95% CI: 0.07-0.33, NNT: 2, 95% CI: 1.3-2.1).

Ondansetron may be an effective and efficient treatment that reduces the incidence of vomiting from gastroenteritis during both the first 8 h and the next 24 h, and is probably a useful adjunct to oral rehydration.

A randomized, double blind, placebo-controlled trial was performed in our emergency departments. Antiemetic medications for pregnancy Children, aged 5 months to 8 years, were randomized to receive either ondansetron 0.2 mg/kg or placebo at 8h intervals. Cerenia antiemetic for dogs The primary outcome measure was the frequency of emesis during an 8-h-period after enrollment.

A hundred and nine patients were enrolled; 54 received placebo and 55 received ondansetron. Antiemetic drugs in pakistan As compared with the children who received placebo, children who received ondansetron were less likely to vomit both during the first 8-h follow-up in the emergency department [relative risk (RR): 0.33, 95% CI: 0.19-0.56, NNT: 2, 95% CI: 1.6-3.5], and during the next 24-h follow-up (RR: 0.15, 95% CI: 0.07-0.33, NNT: 2, 95% CI: 1.3-2.1).

Ondansetron may be an effective and efficient treatment that reduces the incidence of vomiting from gastroenteritis during both the first 8 h and the next 24 h, and is probably a useful adjunct to oral rehydration.