Ulcers gastritis and indigestion – the mini-gastric bypass

The degree of gastric damage following to exposition of the mucosa to noxious agents depends upon a balance between the factors promoting this damage and those activating the natural defense mechanisms.

Recent findings, presented in this review, provide evidence that melatonin prevents the formation of acute gastric lesions induced by stress and accelerates healing of chronic gastric ulcers due to increase in the activity of nitric oxide (NO) synthase (NOS)-NO and cyclooxygenase (COX)-prostaglandin E(2) (PGE(2)) systems resulting in the increase of mucosal blood flow and mucosal integrity.

Due to its anti-inflammatory and anti-oxidant properties, melatonin may be one of the most efficient protective factors preventing the development of acute gastric damage and accelerating healing of chronic gastric ulcers probably due to reduction in proinflammatory cytokine production, scavenging of the radical oxygen species and activation of COX-PG and NOS-NO systems as well as stimulating the afferent sensory nerves in the brain-gut axis.

J Physiol Pharmacol.

Heartburn heart attack 2006 Nov;57 Suppl 5:51-66.Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers. Causes of chronic heartburn Konturek SJ, Konturek PC, Brzozowski T. When does heartburn start during pregnancy Department of Clinical Physiology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland. Home remedy for heartburn vinegar mpkontur@cyf-kr.edu.pl

Serious adverse events are extremely rare for PPIs, with case reports of interstitial nephritis with omeprazole, hepatitis with omeprazole and lansoprazole, and disputed visual disturbances with pantoprazole and omeprazole.

In the absence of Helicobacter pylori infection, the long-term use of PPIs has not been convincingly proven to cause or be associated with the progression of pre-existing chronic gastritis or gastric atrophy or intestinal metaplasia.

Long-term use of PPIs does not lead to vitamin B12 deficiencies, except possibly in the elderly, or in persons with Zollinger-Ellison Syndrome who are on high doses of PPI for prolonged periods of time.

Thus, in summary, the PPIs are a safe class of medications to use long-term in persons in whom there is a clear need for the maintenance of extensive acid inhibition.

BACKGROUND: About 50% of the world population is infected with Helicobacter pylori. Heartburn gerd The association of peptic ulcer disease with Helicobacter pylori is well documented. Is heartburn an early pregnancy sign Therefore eradication is obligatory. How to cure heartburn fast However, the high costs of multidrug therapy, the resistance of Helicobacter pylori to antibiotics as well as the sometimes present drug intolerance are limiting factors.

METHODS: The inhibitory effect of 3% hydrogen peroxide, 8.4% sodium bicarbonate, 2% ascorbic acid, citric acid in combination with sodium citrate, 7% and 14% citric acid solutions, respectively, on nine Helicobacter pylori strains were tested in vitro.

RESULTS: Citric acid showed a potent inhibitory activity on growth of Helicobacter pylori strains in vitro. What helps with heartburn while pregnant This was observed not only when citric acid was applied alone but also if citric acid was given together with low concentration of sodium citrate. Recipes for heartburn Two percent ascorbic acid inhibited three, sodium bicarbonate two and hydrogen peroxide one of the nine tested Helicobacter pylori strains, respectively.

CONCLUSIONS: Citric acid is a cheap substance present in many fruits and produced by food industry, and it demonstrated powerful inhibitory effect on the growth of Helicobacter pylori strains. What causes heartburn in early pregnancy On the basis of our findings citric acid should be further evaluated for the eradication of Helicobacter pylori.